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BD is brand new.

The source file '/BDMV/STREAM/00800.m2ts' is corrupt or invalid at offset 387072, attempting to work around
DEBUG: Code 449 at FF7|\*m5S.5|S99xs*=:29399542
DEBUG: Code 0 at vZA2<~8)qjS^6B.w_;t^q:121266810
DEBUG: Code 0 at vZA2<~8)qjS^6B.w_;t^q:121266810
DEBUG: Code 0 at W8g=t\]}@Q]tE68e^:121263728
DEBUG: Code 0 at W8g=t\]}@Q]tE68e^:121263176
DEBUG: Code 0 at W8g=t\]}@Q]tE68e^:29393930
DEBUG: Code 0 at vZA2<~8)qjS^6B.w_;t^q:121266810
DEBUG: Code 0 at QCo\Ec>jV[9:_:(3u":121267500
DEBUG: Code 0 at QCo\Ec>jV[9:_:(3u":121267914
Failed to save title 0 to file Q:/Nya/Who_Framed_Roger_Rabbit_25th_Anniversary_Edition_t00.mkv
0 titles saved, 1 failed

Corrupt files usually means a flaw in the disk or SOMETHING that prevents the drive from successfully reading the disk. "Clean" disks may not be as clean as you think.

I have multiple DVD and BD drives here. Sometimes a disk will refuse to read in one, but show no errors in a different drive. It all comes down to getting the little pits in the disk to reflect the right way.

This is a disc mastering error. Please submit a full debug log file (as written by MakeMKV, it contains all necessary data) to support@makemkv.com and workaround will be added.

Requested log sent.

Thanx for your time and effort!

Henrik.