www.makemkv.com

For the initial read I get this report:

MakeMKV v1.8.7 darwin(x86-release) started
Optical drive "DVD+R-DL MATSHITA DVD-R UJ-898 HC10d" opened in OS access mode.
Optical drive "BD-RE TSSTcorp BDDVDW SE-506BB TS00d" opened in OS access mode.
Using direct disc access mode
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '11362836480'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '8504801280'
File 00000.mpls was added as title #0
File 00307.mpls was added as title #1
Title #00100.mpls has length of 111 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00201.mpls(1) has length of 15 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00306.mpls was added as title #2
File 00311.mpls was added as title #3
File 00315.mpls was added as title #4
File 00318.mpls was added as title #5
File 00323.mpls was added as title #6
File 00331.mpls was added as title #7
Title #00004.m2ts has length of 1 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00006.m2ts has length of 1 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00007.m2ts has length of 30 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00008.m2ts has length of 19 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00009.m2ts' at offset '589824'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00009.m2ts' at offset '589824'
Failed to decode audio/video data for title #8 - invalid mux or internal error, title skipped.
Title #00009.m2ts was skipped
Title #00010.m2ts has length of 84 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00011.m2ts has length of 102 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00012.m2ts' at offset '0'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00012.m2ts' at offset '0'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00012.m2ts' at offset '0'
Title #00012.m2ts was skipped
Title #00013.m2ts has length of 38 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00024.m2ts has length of 11 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00025.m2ts has length of 8 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00026.m2ts has length of 24 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00027.m2ts has length of 7 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00029.m2ts' at offset '129024'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00029.m2ts' at offset '589824'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00029.m2ts' at offset '589824'
Failed to decode audio/video data for title #8 - invalid mux or internal error, title skipped.
Title #00029.m2ts was skipped
File 00030.m2ts was added as title #8
File 00031.m2ts was added as title #9
File 00032.m2ts was added as title #10
File 00033.m2ts was added as title #11
File 00034.m2ts was added as title #12
File 00035.m2ts was added as title #13
File 00036.m2ts was added as title #14
Title #00037.m2ts has length of 66 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00038.m2ts has length of 71 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00039.m2ts was added as title #15
Title #00040.m2ts has length of 74 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00041.m2ts was added as title #16
Title #00042.m2ts has length of 70 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00043.m2ts has length of 23 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00044.m2ts was added as title #17
Title #00045.m2ts has length of 24 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00046.m2ts has length of 37 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00047.m2ts was added as title #18
Title #00048.m2ts has length of 89 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00049.m2ts was added as title #19
Title #00050.m2ts has length of 103 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00051.m2ts was added as title #20
Title #00052.m2ts has length of 110 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00053.m2ts has length of 55 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Operation successfully completed

Then if I try to go ahead with it I get this:

Saving 1 titles into directory /Volumes/My Passport/Movies
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '393216'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '393216'
Failed to save title 0 to file /Volumes/My Passport/Movies/Storage_24_t00.mkv
0 titles saved, 1 failed

Can someone help me? Thanks!

Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '393216'

This is the operating system telling MakeMKV that part of the disk cannot be read. The fact that the report is isolated to a single MTS file points to the disk itself, rather than the drive.

Initial response is to try cleaning the disk, as finger prints and other smudges can cause this, as can scratches. And yes, new disks can be scratched and dirty.

Also possible is that the disk was not manufactured properly, such as a defect in the pressing. In which case, the only option is returning it for replacement, hopefully with a disk not from the same production batch.