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I've been backing up a lot of my blu-rays recently, and for the most part Cyberlink PowerDVD has been playing the BDMV/ISO(made with IMGBurn) files just fine, but I have one particular blu-ray so far where PowerDVD won't play the rip at all, but the physical disc seems to be just fine. I get no errors during the ripping process whatsoever. When I try to play the file with PowerDVD I get the loading disc bar followed by a black screen and nothing happens. This is in reference to both the ISO and BDMV versions. However, extracting the individual video file of the main feature worked just fine for the disc in question.

What could be the issue?

PowerDVD has anti-piracy measures that will reject some titles if you are playing from anything but an original optical disk.

Have you tried it with a non-official Blu-Ray Certified player?