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I tried to Rip two different copies of Rambo: First Blood in two different drives in two different computers on newest version of MakeMKV, no dice.

I gave up, moved onto Rambo II and III.

Both Failed:
Rambo 2:
MakeMKV v1.10.1 win(x64-release) started
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24360777728'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24509937664'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24360777728'
Using direct disc access mode
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24360777728'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24360777728'
Loaded content hash table, will verify integrity of M2TS files.
File 00008.mpls was added as title #0
File 00002.mpls was added as title #1
Title #00003.m2ts has length of 5 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00004.m2ts has length of 5 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00005.m2ts has length of 23 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00006.m2ts was added as title #2
Title #00007.m2ts has length of 5 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00012.m2ts was added as title #3
Title #00013.m2ts has length of 61 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00008.m2ts has length of 42 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00009.m2ts has length of 42 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Operation successfully completed
Saving 1 titles into directory Z:/Movies/DVDs/rambo2
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom1' at offset '24360777728'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '15541794816'
Failed to save title 1 to file Z:/Movies/DVDs/rambo2/title01.mkv
0 titles saved, 1 failed



RAMBO 3:
MakeMKV v1.10.1 win(x64-release) started
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24509937664'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24360777728'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24509937664'
Using direct disc access mode
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24509937664'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24509937664'
Loaded content hash table, will verify integrity of M2TS files.
File 00008.mpls was added as title #0
File 00002.mpls was added as title #1
Title #00003.m2ts has length of 5 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00004.m2ts has length of 5 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00005.m2ts has length of 23 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00006.m2ts was added as title #2
Title #00007.m2ts has length of 5 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00012.m2ts was added as title #3
Title #00013.m2ts has length of 61 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00008.m2ts has length of 45 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00009.m2ts has length of 43 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Operation successfully completed
Saving 1 titles into directory Z:/Movies/DVDs/rambo3
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '24509937664'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16073293824'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16073293824'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00002.m2ts' at offset '16190140416'
Failed to save title 1 to file Z:/Movies/DVDs/rambo3/title01.mkv
0 titles saved, 1 failed

The type of errors you are getting point to a problem with the drives.

If it were one disk in both drives, I'd say it was the disk; If it were all disks in one drive, I'd say it was that drive. But 4 different disks in two different drives, same type of errors, is highly unusual.

I would think that the common problem present in the scenario of so many different DVD's (4) and Drives (3) in different PCs (2) is that the software is the issue.

Software is the controlled variable.

Yes, the software is common in the scenarios, but the other common element is that the hardware (drive) is telling the operating system that it can't read the disk.

Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading 'BD-RE PIONEER BD-RW BDR-209D 1.34' at offset '24360777728'

MakeMKV is reporting this error, not generating it. When the drive can read the disk but the results are not what MakeMKV expected to see, you'll see "debug code XXXX" in the message, rather than a SCSI or Posix (Linux's and Apple's version of the SCSI report) error.

That's why this seems so strange.

In the case of Rambo 3, the offset to the uncorrectable error changes, which means that the drive WAS able to read some sectors after multiple tries. Which again points to a problem with the disk itself.

You're welcome to try downgrading to an earlier version of MakeMKV if you think that's the problem: /download/old/

But the error messages do not support that hypothesis.