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I am attempting to backup my copy of Django Unchained (Blu-ray) and am receiving the following error stream. I have successfully worked with 50 or so DVDs so far, and this was the first error I have encountered. Any help would be appreciated.

Saving 1 titles into directory /Volumes/DVD Drive/Django Unchained
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394601984'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
DEBUG: Code 1073741829 at !<t@/W*KKFu/M]@qE2:121262969
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
DEBUG: Code 100860416 at !<t@/W*KKFu/M]@qE2:121262969
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
DEBUG: Code 0 at y0'(,k6zr!"t-8B-z*t<:121263291
DEBUG: Code 0 at _Z,(O/ A,th<R]rk8F>[:121262302
DEBUG: Code 0 at y0'(,k6zr!"t-8B-z*t<:213130812
DEBUG: Code 680958 at y0'(,k6zr!"t-8B-z*t<:29393286
DEBUG: Code 0 at mG<:=b9W,P~ormm]K)|z[:29398967
DEBUG: Code 0 at mG<:=b9W,P~ormm]K)|z[:29398967
LIBMKV_TRACE: Exception: Error while reading input
Failed to save title 0 to file /Volumes/DVD Drive/Django Unchained/Django_Unchained_t00.mkv
0 titles saved, 1 failed

sorry, missed some of the message. Complete message below:

Saving 1 titles into directory /Volumes/DVD Drive/Django Unchained
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394601984'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1394606080'
DEBUG: Code 1073741829 at !<t@/W*KKFu/M]@qE2:121262969
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
DEBUG: Code 100860416 at !<t@/W*KKFu/M]@qE2:121262969
Error 'Scsi error - MEDIUM ERROR:NO SEEK COMPLETE' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1394601984'
DEBUG: Code 0 at y0'(,k6zr!"t-8B-z*t<:121263291
DEBUG: Code 0 at _Z,(O/ A,th<R]rk8F>[:121262302
DEBUG: Code 0 at y0'(,k6zr!"t-8B-z*t<:213130812
DEBUG: Code 680958 at y0'(,k6zr!"t-8B-z*t<:29393286
DEBUG: Code 0 at mG<:=b9W,P~ormm]K)|z[:29398967
DEBUG: Code 0 at mG<:=b9W,P~ormm]K)|z[:29398967
LIBMKV_TRACE: Exception: Error while reading input
Failed to save title 0 to file /Volumes/DVD Drive/Django Unchained/Django_Unchained_t00.mkv
0 titles saved, 1 failed
Saving 1 titles into directory /Volumes/DVD Drive/Django Unchained
Error 'Scsi error - HARDWARE ERROR:TRACK FOLLOWING ERROR' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1395259392'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1395259392'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1395261440'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1395261440'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1395261440'
Error 'Posix error - Input/output error' occurred while reading '/dev/rdisk3' at offset '1395261440'
Error 'Internal error - Operation was cancelled (112)' occurred while reading '/BDMV/STREAM/05024.m2ts' at offset '1395259392'
DEBUG: Code 0 at y0'(,k6zr!"t-8B-z*t<:121263291
DEBUG: Code 0 at _Z,(O/ A,th<R]rk8F>[:121262302
DEBUG: Code 0 at y0'(,k6zr!"t-8B-z*t<:213130812
DEBUG: Code 681279 at y0'(,k6zr!"t-8B-z*t<:29393286
DEBUG: Code 0 at mG<:=b9W,P~ormm]K)|z[:29398967
DEBUG: Code 0 at mG<:=b9W,P~ormm]K)|z[:29398967
LIBMKV_TRACE: Exception: Error while reading input
Failed to save title 0 to file /Volumes/DVD Drive/Django Unchained/Django_Unchained_t00.mkv
0 titles saved, 1 failed

The error messages indicate the drive is not able to read parts of the disk; first it can't seek to a particular location (NO SEEK COMPLETE), then it appears to become unresponsive for a period of time.

Is this an external drive, or internal? Some USB-connected drives will go off-line when they are run at maximum speed, but this error can occur with damaged disks as well.

not sure what the problem is. I rip a separate disk and it works fine. The DVD has never been out of the case and there aren't any visible marks on the disc to indicate damage.

I said it is possible the disk has issues, but the errors indicate a hardware issue. Why is the drive going off-line?

This scenario fits the errors you are seeing, assuming you're using a USB powered drive:

Drive spins up to read fast. It reaches a point where it must change head position to get to the next spot on the disk. The combined power needed to spin and move the head is too much for the available power on the USB port you're plugged into. The drive electronics go off-line momentarily and reset. The operating system reports a hardware failure.

You clipped off the part of the log where it reports what type of drive is involved, so I am only guessing here, but it fits the error messages.