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I tried to extract a DVD boxset for STUDIO 60 ON THE SUNSET STRIP.

2 episodes would not rip, one title from Disc 3 and one title from Disc 6.
Repeated errors "corrupt or invalid at offset" at various locations. Eventually fail.
Tried cleaning the disc, no difference.
Tried 3 different DVD drives, same results.
All other title work fine, rip quickly-- but those two fail repeatedly.

Although the disc surface looks perfectly clean, I assumed it was a disc error.
So I just bought another copy.
Same result on DIFFERENT DISCS.
Repeated errors "corrupt or invalid at offset" at various locations.
Tried 3 different drives, same result.
All other titles work fine, these two collapse in repeated errors.

So is this just something unworkable? Did they create a disc that seems to play fine but cannot be ripped cleanly?

Some disks have manufacturing errors, and the entire lot will be unreadable at the same spot. I went through multiple sets on the Hercules TV series like that, INCLUDING disks from Netflix. I ultimately had to use a DVD-only drive to read the particular disk; none of my BD drives could.

If the location varies between copies, it is more likely a contamination issue. The longer disks are in their packaging, the worse they get. Check the "if you're experiencing rip errors" topic in the Bluray forum for ways to clean disks.

I've ripped the us studio 60 on the sunset strip in the past, so i know for a fact that it was rippable about a decade ago.