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Hallo here is a question from a newbee,
I'll get this failure directly after starting makemkv 1.6.5

MakeMKV v1.6.5 darwin(x86-release) started
Optical drive "BD-RE PLEXTOR BD-R PX-LB950UE 1.01" opened in DASPI mode.
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '524288'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '1048576'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '32768'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '524288'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '1048576'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '32768'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '524288'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '1048576'
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'BD-RE PLEXTOR BD-R PX-LB950UE 1.01' at offset '32768'
Failed to open disc

This is an external Bluray Drive, but I get the same problem with a DVD and the internal Drive (Macbook pro - latest OS).

By using 1.6.2 it was ok with the internal drive.

Uninstalling and new installation - same problem!
Please help

Please enable "log debug messages" in preferences and see if any errors show up. Also please make sure that you're running the latest DASPI version, v1.2

The latest Version DASPI 1.2 is running.
And here is the log (internal drive and dvd)

MakeMKV v1.6.5 darwin(x86-release) started
Debug logging enabled, log will be saved as /Users/markusglagla/MakeMKV_log.txt
Optical drive "DVD+R-DL MATSHITA DVD-R UJ-898 HC09" opened in DASPI mode.
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:29395885
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:121262049
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'DVD+R-DL MATSHITA DVD-R UJ-898 HC09' at offset '524288'
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:29395885
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:121262049
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'DVD+R-DL MATSHITA DVD-R UJ-898 HC09' at offset '1048576'
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:213132560
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:121262049
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'DVD+R-DL MATSHITA DVD-R UJ-898 HC09' at offset '32768'
DEBUG: Code 0 at ?hyY!pY\qW%1 nGi$k?:29393447
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:29395885
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:121262049
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'DVD+R-DL MATSHITA DVD-R UJ-898 HC09' at offset '524288'
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:29395885
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:121262049
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'DVD+R-DL MATSHITA DVD-R UJ-898 HC09' at offset '1048576'
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:213132560
DEBUG: Code 4294967295 at K|cLd{ope%9ew1RFdJ:121262049
Error 'OS error - ERROR_FFFFFFFF' occurred while reading 'DVD+R-DL MATSHITA DVD-R UJ-898 HC09' at offset '32768'
DEBUG: Code 0 at ?hyY!pY\qW%1 nGi$k?:29393447