Version 1.14.4 tells me always that there is no disc inserted.
With version 1.14.3 the drive make several minutes terrible sounds before it starts
Perhaps this will help:
Does MakeMKV 1.14.4 have issues with this UHD?MakeMKV v1.14.3 win(x64-release) started
Debug logging enabled, log will be saved as C:\Users\Rainer/MakeMKV_log.txt
The new version 1.14.4 is available for download at http://www.makemkv.com/download/
Backing up disc into folder "D:/DVD/MakeMKV/backup/BIG_PACIFIC"
Using LibreDrive mode (v05 id=E064BA3E3F81)
Downloading latest HK to C:\Users\Rainer/.MakeMKV ...
Loaded content hash table, will verify integrity of M2TS files.
Encountered 2 errors of type 'Read Error' - see http://www.makemkv.com/errors/read/
Backup done