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I have tried ripping Step Brothers UHD 4K with 3 different discs. Tried cleaning them all and I get the same results.

Log below:

MakeMKV v1.14.7 win(x64-release) started
Using direct disc access mode
Evaluation version, 30 day(s) out of 30 remaining
Using LibreDrive mode (v05 id=62194E19F4EC)
Loaded content hash table, will verify integrity of M2TS files.
File 00102.mpls was added as title #0
File 00257.mpls was added as title #1
File 00258.mpls was added as title #2
File 00259.mpls was added as title #3
File 00260.mpls was added as title #4
Title #00100.m2ts has length of 14 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00104.m2ts has length of 0 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00001.m2ts has length of 30 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00116.m2ts has length of 11 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00208.m2ts has length of 10 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00080.m2ts has length of 13 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00081.m2ts has length of 13 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00335.m2ts has length of 59 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Title #00082.m2ts has length of 13 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00336.m2ts was added as title #5
Title #00337.m2ts has length of 23 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00338.m2ts was added as title #6
File 00339.m2ts was added as title #7
Title #00340.m2ts has length of 76 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00341.m2ts was added as title #8
File 00342.m2ts was added as title #9
File 00343.m2ts was added as title #10
File 00344.m2ts was added as title #11
File 00345.m2ts was added as title #12
File 00346.m2ts was added as title #13
File 00347.m2ts was added as title #14
File 00348.m2ts was added as title #15
Title #00349.m2ts has length of 50 seconds which is less than minimum title length of 120 seconds and was therefore skipped
File 00350.m2ts was added as title #16
File 00351.m2ts was added as title #17
File 00352.m2ts was added as title #18
File 00353.m2ts was added as title #19
Title #00354.m2ts has length of 13 seconds which is less than minimum title length of 120 seconds and was therefore skipped
Operation successfully completed
Saving 1 titles into directory C:/Video/Step Brothers
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '190144512'
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '190144512'
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '190144512'
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '190144512'
Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '190144512'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'
Failed to save title 3 to file C:/Video/Step Brothers/Step Brothers_t03.mkv
Encountered 11 errors of type 'Read Error' - see http://www.makemkv.com/errors/read/
0 titles saved, 1 failed

Your drive found a spot it couldn't read:

Error 'Scsi error - MEDIUM ERROR:L-EC UNCORRECTABLE ERROR' occurred while reading '/BDMV/STREAM/00341.m2ts' at offset '190144512'

Then it spent a long time trying to read it, and Windows decided it was off-line:

Error 'OS error - STATUS_DEVICE_DATA_ERROR' occurred while reading '\Device\CdRom0' at offset '190144512'

Usually that means you have a dirty spot on the disk, and cleaning will take care of it. Yes, even if it looks "perfectly clean".

That would be an amazing coincidence that 3 random discs all had the same dirty spot on a UHD disc that were bought at 3 different times. Cleaning the disc on all 3 copies did not make a difference. I have ripped over 200 UHD 4K HDR discs and this is the only movie that wont burn. Don't think your analogy of simply cleaning it for 3 separate discs is the correct assessment.

Correct. It suggests a drive problem with reading that particular disc.

I have had this same issue with two different disc as well. I have a had a few disc that fail but usually after getting a replacement everything works. I think it might be the subpar quality of the disc used for the release.